Accordingly, a multicenter, open-label, randomized controlled trial investigating the effects of the IL-1 inhibitor Anakinra in T2DM patients showed a significant reduction in the HbA1c (glycated hemoglobin A1c) %, after correcting for clinical confounders, such as sex, age, disease duration, use of oral antidiabetic drug, and body mass index [57]. The gene discussed is IL1B; the disease is type 2 diabetes mellitus.