SOD1 and idiopathic membranous glomerulonephritis: Also, Nrf2 expression and its downstream antioxidants were responsible for the protective response against OS in MGN rats, while negative regulators of Nrf2, such as Keap1 and oxidants such as MDA, were enhanced, with a decline in the level of antioxidants, including SOD, CAT, and GPx [54].