Due to its progressive nature, type 2 diabetes requires a gradual intensification of treatment, starting usually with monotherapy, through the use of 2–3 oral medications, up to injectable therapies with the use of GLP-1 (Glucagon-like peptide-1) receptor agonists and/or various insulin therapy regimens, with or without oral medications [69,70]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.