INS and cancer: The production of resistin, leptin, PAI-1 (plasminogen activator inhibitor-1) and VEGF (vascular endothelial growth factor) as well as inflammatory cytokines: TNF-α (tumor necrosis factor-α), IL-6 (interleukin-6), IL-1β (interleukin 1β), MCP-1 (monocyte chemoattractive protein-1) and CRP (C-reactive protein) increases, while production of adiponectin, which improves insulin sensitivity, inhibits angiogenesis, protects against inflammation and which is also (in vitro) an inhibitor of cell growth and proliferation of certain cancers, decreases.