For instance, IL-1R signaling was shown to drive intestinal inflammation in DSS-induced colitis, as mice deficient in the single immunoglobulin IL-1 receptor-related IL-1 pathway inhibitory molecule (SIGIRR, also known as TIR8) [163] were more susceptible to DSS-induced colitis compared to controls [164,165]. The gene discussed is IL1A; the disease is colitis.