Furthermore, antibody-mediated neutralization of IL-17RA or IL-17A led to enhanced colitis in Abcb1a−/− mouse model (Abcb1a gene in mice encodes the P-glycoprotein-ATP-dependent transporter) that was associated with increased intestinal permeability and reduction in antimicrobial peptide β-defensin, RegIIIγ, and S100A8 expression [188]. This evidence concerns the gene IL17A and colitis.