Preoperative increased CRP levels did not correlate to smoking anamnesis; one out of six melanoma patients with BM (20%) was a smoker and exhibited preoperative CRP levels > 10 mg/L compared to six smokers out of 24 (25%) patients with preoperative CRP levels ≤ 10 mg/L (p = 1.0). The gene discussed is CRP; the disease is melanoma.