A similar, although weaker chaperone activity against α-synuclein aggregation (in vitro, in the yeast α-synuclein model, and in murine neuroblastoma cells) has been reported for human DJ-1, and PD-causing DJ-1 mutations were shown to decrease the interaction with α-synuclein [12,56,59]. The gene discussed is SNCA; the disease is Parkinson disease.