PD-associated DJ-1 mutations (L10P, M26I, A104T, D149A and L166P) were shown to impair or abolish this detoxification activity, suggesting that further dissection of the methylglyoxal-adduct hydrolase activity of DJ-1, which protects low-molecular thiols from dicarbonyl damage, may be a promising research direction to progress in our understanding of PD pathophysiology [40]. Here, PARK7 is linked to Parkinson disease.