In particular, a member of the Ca2+–activated chloride channels, TMEM16A, also known as ANO1, was proposed to contribute to tumor growth and invasion in head and neck squamous cell carcinomas, breast cancer, hepatocellular carcinoma, lung cancer, gastric cancer, and prostate cancer [138,139,140,141,142,143]. This evidence concerns the gene ANO1 and head and neck squamous cell carcinoma.