The robust linear inverse association between plasma adiponectin concentrations and type 2 diabetes risk observed in our population, mainly in women, is concordant with other reports where associations with adiponectin levels were stronger in individuals with a higher metabolic risk profile [77,78,79], supporting the idea that the association between adiponectin concentrations and type 2 diabetes is stronger in subjects with higher BMI. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.