ADIPOQ and type 2 diabetes mellitus: (1) To study the association between four pre-selected candidate gene variants: −11391 G/A (rs17300539); +45T > G (rs2241766); +276G > T (rs1501299); and rs17366568 (G > A), in the ADIPOQ gene on adiponectin levels and related traits (plasma lipids, adiposity and type 2 diabetes), as the main effect, and to analyze the gene-diet interactions with the Mediterranean dietary pattern in a high-cardiovascular risk Mediterranean population.