SIRT1 and hydrops fetalis: In six-month-old transgenic mice, a 12.5-fold increase in the overexpression of Sirt1 paradoxically resulted in mitochondrial dysfunction and detrimental effects in heart function and morphology, namely, reduced EF and LVH, characteristics of HF, compared with a 2.5–7.5-fold increase in the overexpression of Sirt1 [219].