The addition of newly reported findings including ataxia, poor coordination, seizures, and congenital anomalies including palatal, heart, and ear defects along with structural brain disturbances [11] which are also associated with the four genes in the 15q11.2 BP1-BP2 region raises the question of whether these genes interact with other genes, their biological processes or molecular functions. The gene discussed is IGFBP2; the disease is Ataxia.