Very heterogenic immune cell infiltration in MPM tumor specimens and its TME has been described [29,30,31,32,33], with most studies reporting a predominant infiltration of tumor-associated macrophages (TAM) and tumor infiltrating lymphocytes (TIL), in particular CD4+ and CD8+ T-lymphocytes as reviewed by Chu et al. [34]. This evidence concerns the gene CD4 and neoplasm.