In mesothelioma cells, among the angiogenesis-related proteins, angiopoietin-1, thrombospondin-1 (TSP-1), and tissue inhibitor of metalloproteinases-1 (TIMP-1) were significantly downregulated upon SDC-1 over-expression, whereas IL-8 was upregulated upon SDC-1 silencing. Here, THBS1 is linked to mesothelioma.