Berberine upregulated LC3-II and induced autophagy in glioblastoma through the regulation of the AMPK/mTOR/unc-51 like autophagy activating kinase 1 (ULK1)-pathway [80] and repressed human gastric cancer cell proliferation through inactivation of the MAPK/mTOR/p70S6K/Akt signaling pathway in vivo and in vitro [81]. This evidence concerns the gene ULK1 and gastric cancer.