In years past, CFTR intragenic polymorphic microsatellites analysis indicated that IVS8CA alleles 181 (CA16) and 183 (CA17) on intron 8 of the CFTR gene were significantly associated with resistance to enteric fever and van de Vosse et al. also identified that both IVS8CA genotypes of 181/181 and 181/183 have a protective effect for typhoid fever in a case-control study in Indonesia [17]. The gene discussed is CFTR; the disease is typhoid fever.