FLT3 and cancer: The Pim kinases overexpression observed in cancer cells results from the abnormal activation of upstream kinases (e.g., BCR-Abl, Jak2) or receptor tyrosine kinases (RTK) (e.g., fms-like tyrosine kinase 3 (FLT3)-ITD), responsible for the activation of the signal transducer and activator of transcription (STAT) family transcription factors (particularly STAT 3/5) [13].