In the vast majority of cases, ALCL is characterized by constitutive expression of anaplastic lymphoma kinase (ALK) fusion proteins due to the presence of chromosomal translocations involving the ALK gene on chromosome 2, the most frequent of which is the t(2;5)(p23;q35), juxtaposing the ALK kinase domain coding sequence to NPM1 oligomerization domain [2]. The gene discussed is NPM1; the disease is anaplastic large cell lymphoma.