NPM1 and anaplastic large cell lymphoma: Proteins of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway were of particular interest since the nucleophosmin (NPM)-ALK fusion protein of ALCL cells is known to activate several interconnected oncogenic signaling pathways, including RAS-extracellular signal-regulated kinase (ERK), Janus kinase 3 (JAK3)- Signal Transducer and Activator of Transcription 3 (STAT3) and phosphatidylinositol 3-kinase (PI3K)-AKT [20].