HSP90AA1 and anaplastic large cell lymphoma: By Western blotting analysis, we confirmed that TNC, SPP1 (better known as OPN) and HSP90AA1 were significantly more abundant in ALCL plasmatic S-EVs compared to HD (Figure 4d, Mann–Whitney p = 0.0004, p = 0.0008 and p = 0.0004, respectively).