Interestingly, low relative abundance of Ruminococcaceae were registered at one week of age in infants that developed IgE-associated eczema, and low abundance of the genus Ruminococcus at that age was associated with exaggerated Toll-Like Receptor (TLR)-2-induced interleukin (IL)-6 and Tumor necrosis factor (TNF)-α responses at 6 months [46]. This evidence concerns the gene IGHE and Eczematoid dermatitis.