MRC1 and pancreatic neoplasm: It has been reported that the patients with germline mutations of the MMR gene demonstrate a cumulative risk of 1.31% of developing pancreatic cancer by the age of 50 years and a cumulative risk of 3.68% of developing pancreatic cancer by the age of 70 years, and the risk is estimated to be 8.6 times more that of the general population [58].