Of note, the fold-increase of CXCR5 expression in SLE CD4 T-cells stimulated with carb-LL37 not only significantly correlated with the magnitude of antibody reactivity to anti-carb-LL37 (Spearman r = 0.41, P = 0.049, N = 17) but also with the anti-native LL37 antibody response (Figure 4e). This evidence concerns the gene CD4 and systemic lupus erythematosus.