MAP2K1 and hepatocellular carcinoma: In cultured HCC cells, DCP stimulates HCC growth and metastasis through activation of MMP2 and MMP-9 due to binding to c-Met receptor and causing its phosphorylation followed by epidermal growth factor receptor (EGFR) activation with subsequent ERK1/2, MEK1/2, and c-Raf (MAPK signaling) stimulation [91].