Supplementation of other multi-strain probiotics, which include species of Bifidobacterium, Lactobacillus, and Streptococcus have demonstrated beneficial modulations in the gut microbiome, which are associated with increased secretion of SCFAs (mainly butyrate), improved glycemic control and insulin sensitivity, and reduced gut permeability in T2D [17,37,38,39]. This evidence concerns the gene INS and type 2 diabetes mellitus.