The parameters measured were obesity parameters (BMI, Lee index, abdomino-thoracic circumferences), lipid and metabolic profiles (TC, TG, LDL, HDL, leptin and adiponectin), aortic oxidative stress status, and immunoexpression of aortic pro and anti-inflammatory markers, as well as aortic and adipocyte histological changes. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.