In VVC, however, there is significant neutrophil recruitment, but these neutrophils are unable to control the infection, and several environmental factors, including the heparan-sulphate-dependent inhibition of CR3 recognition and reduced Dectin-1 recognition due to lactate inducing β-glucan masking, have been suggested to account for this nonprotective innate immune response. The gene discussed is CRIPTO3; the disease is infection.