Conversely, to provoke a CIN phenotype, the SAC can be alleviated by the use of drugs that interfere with SAC proteins such as the MPS1 inhibitors AZ3146 [16] and Reversine [17], or the Mad2 inhibitor M2I-1 [18] by genetically alleviating SAC proteins such as Mps1, Mad2, or Bub1 [19,20,21]. This evidence concerns the gene ADCY10 and cervical squamous intraepithelial neoplasia.