STUB1 and cancer: Using data from the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) from 21,146 patients with different types of cancer, Bolton et al. [55] recently found that CHIP was present in 30% of patients at a median VAF of 5% (range 2–78%), with 31% of cases harboring more than one lesion.