ICAM1 and infection: However, the pathogen also secretes severe proteins that interfere with neutrophil recruitment, including the Chemotaxis Inhibitory Protein (CHIP) and the Extracellular adherence protein (Eap), which, respectively, block neutrophil recognition of chemotactic factors [28] and neutrophil binding to endothelial adhesion molecule, intercellular adhesion molecule-1 (ICAM-1) [29] required for neutrophil adhesion, diapedesis, and extravasation from the bloodstream to the site of infection.