Moreover, dopaminergic cells in PGC-1α knockout mice were more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydrodropyridine (MPTP), a well-known neurotoxin which causes selective degeneration of the substantia nigra, like in PD, after systemic administration [188,189,190]. The gene discussed is PPARGC1A; the disease is Parkinson disease.