While previous studies in the Amish examined congenital glaucoma [60] or described glaucoma as a clinical feature in a few individuals with a homozygous mutation in the SAMHD1 gene associated with cerebral vasculopathy and early onset stroke [61], glaucoma risk and prevalence have not been extensively studied in the Amish population. The gene discussed is SAMHD1; the disease is congenital glaucoma.