IL6 and neoplasm: Other evidence on the cross-talk between GBM and microglia comes from the finding reported by Yang et al.; they demonstrated that miR-214-5p, aberrantly upregulated in GBM cells, can be transferred to microglia, through exosomes, contributing to the suppression of microglial C–X–C motif chemokine receptor 5 (CXCR5), and, consequently, increasing the microglial secretion of inflammatory cytokines IL-6, IL-8, and TNF-α, which, in turn, favor a tumor-supportive microenvironment [77].