Li et al. demonstrated that temozolomide (TMZ)-resistant GBM cells trigger the M2-polarization of microglial cells thanks to the long-noncoding RNA SNHG15 (upregulated in GBM cells), and its associated molecular axis made up of miR-627 (tumor suppressor, normally downregulated in GBM) and CDK6 (oncoprotein, directly targeted by miR-627) [85]. Here, CDK6 is linked to glioblastoma.