The genotype combinations GA (rs889299) and TT CPA6 rs2162145, GA (rs889299) and TC (rs2162145), and TT (rs2162145) and GG (rs889299) were prominently detected among patients with uncontrolled T2DM (HbA1c > 7%) The combination GA (rs889299) and TT rs2162145 was associated with uncontrolled T2DM (Figure 1). This evidence concerns the gene CPA6 and type 2 diabetes mellitus.