An analysis of the cellular distribution of P2RY12 protein, performed in post-mortem cortex samples from MS patients as well as healthy human subjects, showed that P2RY12 was present in myelin and interlaminar astrocytes but absent from protoplasmic astrocytes in deeper cortical layers, from microglia/macrophages, and from intact demyelinated axons [92]. Here, P2RY12 is linked to myeloid sarcoma.