Furthermore, spatially concordant mutations were found in BTG2, MYD88, CD58, HIST1H1C, HIST1H1D, HIST1H2AG, EP300, and KMT2D. However, two patients showed heterogenous CARD11 mutations and patient 1 harboured two heterogenous MYC mutations, which were only found in biopsy 5 (TU5) but not in the other five lymphoma biopsies. Here, MYD88 is linked to lymphoma.