CT10 regulator of kinase (Crk) and Crk-like (CrkL) are overexpressed in multiple human cancer types, including GBM (8, 9, 10), breast cancer (11, 12, 13), non-small cell lung cancer (14, 15, 16), gastric cancer (17, 18, 19), cervical cancer (20, 21), ovarian cancer (22, 23), endometrial carcinoma (24), oral squamous cell carcinoma (25), bladder cancer (26), rhabdomyosarcoma (27), thyroid cancer (28), pancreatic cancer (29), and colorectal cancer (30). Here, CRK is linked to familial pancreatic carcinoma.