Whereas PD-L1 expressed on the surface of cancer cells inhibits activation of T cells by interacting with PD-1, a role that forms the basis for its therapeutic targeting by antibodies (31), a recent report highlights another role of intracellular PD-L1 in stabilizing the mRNA of DNA damage/repair proteins (e.g. NBS1 and BRCA1) (32). Here, CD274 is linked to cancer.