CRP and insomnia: Specifically, Irwin et al. [25] found that older adults receiving cognitive-behavioral therapy for insomnia (CBT-I), versus a sleep education seminar, exhibited a 74% lower risk of elevated C-reactive protein (CRP; ≥ 3.0 mg/L), an inflammatory marker implicated in and predictive of the development of CVD [26], at the 16-month follow-up.