A recent study found that HBV insertions can cause alterations in CCNA2 and CCNE1, which encode the cell cycle regulators cyclin A2 and cyclin E1, respectively, and that these alterations are associated with a more aggressive HCC phenotype, termed cyclin-driven HCC, which is defined by a unique pattern of frequent chromosomal structural rearrangements consistent with a break-induced replication mechanism [24]. This evidence concerns the gene CCNE1 and hepatocellular carcinoma.