In response to discontinuing the insulin infusion for 5.4 ± 0.6 hours, plasma glucose in participants with T1D increased to an average of 14.4 mmol/L, which was higher than that in ND participants, 4.72 mmol/L, at the same time (P < 0.001) (Table 1). This evidence concerns the gene INS and type 1 diabetes mellitus.