Other reports indicated that the levels of Mannose-binding lectin-associated serine proteases (MASP-1, MASP-1)-C1-INH complexes are lower in C1-INH-HAE patients and correlate with the frequency of attacks [45], whereas the levels of MASP-2 and ficolin-3/MASP-2 complexes increase during attacks [46] (Table 1). This evidence concerns the gene MASP1 and hereditary angioedema.