Studies designed to elucidate the mechanisms of HAE usually are unable to strictly follow the above requirements for biomarker identification, but there are already some ongoing trials directly dedicated to the study of biomarkers in HAE, including specific biomarkers of BK-mediated angioedema attack in a pediatric population, potential disease-specific biomarkers for HAE with the use of dry blood spot technology, and, finally, the use of cHK as a biomarker in C1-INH-HAE [1]. Here, SERPING1 is linked to hereditary angioedema.