Moreover, cardiac fibrosis in the BZ (Figure 3F,G), as well as mRNA levels of Collagen-1 (Col-1), CTGF, and MMP2, were higher in TgGRK5 compared to NLC mice in a chronic phase of HF (8-weeks post-MI) (Figure 3H,J,K). This evidence concerns the gene MMP2 and hydrops fetalis.