,38 However, TgGRK5 mice still show high LV MMP2 mRNA levels at 8 weeks post-MI and this may explain at least in part the increased mortality rate in TgGRK5 mice as MMP-2 has been linked to impaired ECM degradation and increased risk of cardiac rupture.37 The gene discussed is MMP2; the disease is myocardial infarction.