,30,31 Moreover, transcriptome unbiased analysis of post-MI cardiomyocytes with GRK5 overexpression showed altered levels of several genes previously indicated to be involved in cardiac hypertrophy, remodeling or HF such as Kcne1, Efna5, Psmd8 and several regulators of the extracellular matrix.32–35. Here, PSMD8 is linked to cardiac hypertrophy.