Interestingly, our data show significant detrimental effects of cardiomyocyte-specific overexpression of GRK5 in ischemic HF (4- and 8-weeks post-MI) both in terms of contractility and LV dimension (Figure 1D,E and Supplementary material online, Figure S2C, D and Table S1). The gene discussed is GRK5; the disease is hydrops fetalis.