These three genes (LY6E, IFI27 and IFI44) are all type-I interferon-inducible genes (ISGs), demonstrated to have altered expressions in disease states and known to be highly effective at countering infection (Kyogoku et al., 2013; McNab et al., 2015; Rönnblom and Eloranta, 2013; Schneider et al., 2014). The gene discussed is LY6E; the disease is infection.