MS4A4A, IFI44L, OAS2 and IFIT5 are known ISGs; increased levels of MMP8 have been observed in HIV viral studies (Singh et al., 2018); SIGLEC1, a Type 1 transmembrane protein, is expressed by a subpopulation of macrophages found upregulated during in vivo respiratory syncytial virus infections (Jans et al., 2018) and contributes to the initiation of formation of the virus-containing compartment (Hammonds et al., 2017). The gene discussed is SIGLEC1; the disease is respiratory syncytial virus infectious disease.