The uptake of PSMA in the primary tumour have also been proposed as a marker of PCa aggressiveness in a number of studies [6–9]; however, in a recent large study on high-risk patients, we have demonstrated a large overlap in tumour PSMA uptake between International Society of Urological Pathology (ISUP) Grade Groups (GG) [10]. Here, FOLH1 is linked to neoplasm.