Indeed, MBD and CVDs may share common pathogenic pathways: in particular, several molecules (such as bone morphogenetic proteins, receptor activator of nuclear factor κB ligand, osteoprotegerin, matrix Gla protein and cathepsins), the parathyroid hormone–vitamin D–calcium–phosphate biological system, oxidized lipids and vitamin K seem implicated in both bone and cardiovascular metabolism [28–30]. The gene discussed is CTSS; the disease is Marchiafava-Bignami disease.