To identify the molecular pathways by which KDM4C exerts its biological effects in lung cancer, we employed RNA sequencing (RNA-Seq) screening and identified the expression of ~544 genes with significant changes (P value < 0.05 and foldchange absolute value ≥ 2) in KDM4C-depleted cells compared to that in control cells (Fig. 4a). This evidence concerns the gene KDM4C and lung carcinoma.