KDM4C and cancer: Next, using immunohistochemistry (IHC) analysis, we quantified KDM4C protein levels in a human lung cancer tissue microarray consisting of 86 fresh lung adenocarcinoma tissues matched with their adjacent nontumor tissues (NTs) and demonstrated that KDM4C localized to the nucleus and cytoplasm of cancer cells and its protein levels were considerably higher in lung cancer tissues than in adjacent NTs (Fig. 1c, d).