Given that USP9X co-localized with KDM4C and a significant positive correlation between the expression of USP9X and KDM4C in lung cancer tissues was observed (Fig. 8g, h and Supplementary Fig. 5), we conclude that USP9X overexpression may account for KDM4C upregulation in human lung cancer. This evidence concerns the gene KDM4C and lung carcinoma.