In the WAS model, stressed rats showed increased numbers of Iba-1-positive cells in the amygdala and lumbar spinal cord (Fig. 1g, h, Supplementary Table 2) and exhibited Iba-1-positive cells with an ameboid phenotype and decreased morphological parameters; these changes were inhibited by berberine administration (Fig. 1i, j, Supplementary Table 3). The gene discussed is AIF1; the disease is Wiskott-Aldrich syndrome.