BCL2 and chronic myelogenous leukemia, BCR-ABL1 positive: Recently, Nox4, a Nox isoform, was found to be expressed in the mitochondria of chronic myeloid leukemia cells that overexpress the nonapoptotic protein BCL-2 (CEM/BCL-2)59 in the renal cortex of rats60 and of cardiomyocytes, and in membrane fractions enriched with mitochondria.