Interestingly, we found that baicalin, wogonin, and oroxylin A shared multiple overlapped CIR genes, including RELA, IL1B, MAPK14, IL6, STAT3, TNF, GSK3B, and NFKBIA, which indicates that Huangqin may exert cancer immunotherapeutic effect through the synergistic action of these components. Here, TNF is linked to cancer.