Interestingly, we found that baicalin, wogonin, and oroxylin A shared multiple overlapped CIR genes, including RELA, IL1B, MAPK14, IL6, STAT3, TNF, GSK3B, and NFKBIA, which indicates that Huangqin may exert cancer immunotherapeutic effect through the synergistic action of these components. Here, IL1B is linked to cancer.