In the present study, 13 real hub genes (FCGR3A, CCR5, IL2RA, CD86, CYBB, CD4, PRKN, ITPR1, KCNMA1, AOC3, FGF2, ANK2, and MAPK10) tightly associated with GC progression were identified, and a series of bioinformatic analyses showed that these genes were both highly correlated with GC grade and may be potential biomarkers for predicting tumor stage. Here, IL2RA is linked to neoplasm.