In the present study, 13 real hub genes (FCGR3A, CCR5, IL2RA, CD86, CYBB, CD4, PRKN, ITPR1, KCNMA1, AOC3, FGF2, ANK2, and MAPK10) tightly associated with GC progression were identified, and a series of bioinformatic analyses showed that these genes were both highly correlated with GC grade and may be potential biomarkers for predicting tumor stage. Here, PRKN is linked to gastric cancer.