In line with previous results generated from other TMPRSS2 positive cells5,24, camostat mesylate, a clinically proven inhibitor for serine protease including TMPRSS2, significantly attenuated the infection of SARS-CoV-2-S, as indicated by the reduction in luciferase activity, suggesting that TMPRSS2 is also an important factor for facilitating SARS-CoV-2-driven entry into LNCaP cells (Fig. 2a). Here, TMPRSS2 is linked to infection.