Since cochlear hair cells experience considerably more force than vestibular hair cells or the calyceal processes of retinal photoreceptors64, PCDH15–R113G+/+ likely unbinds more rapidly in the cochlea than in the vestibular system or retina, consistent with the more profound deafness phenotype in PCDH15–R113G+/+ human patients compared with the balance or visual phenotype. The gene discussed is PCDH15; the disease is deafness.