This observation, affirmed by analyses localizing individual-patient networks from this study to the human interactome, provides context to prior reports implicating pathogenicity of the same genetic variants in both HCM and DCM, such as MYH6 and ACTN2, among others28, despite the fact these two phenotypes are grossly dissimilar. This evidence concerns the gene MYH6 and familial dilated cardiomyopathy.